Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack targeting an subterranean weapons facility in Syrian territory operated by the IS group, according to the British defence ministry.
The location, pinpointed through reconnaissance, was thought to be housing weapons and explosive materials, the release indicated, and was situated in mountainous terrain just to the north of the historic site of Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to strike a several entry passages leading to the site... early reports are that the target was engaged successfully," officials stated.
There was no sign of any civilian casualties in the strike on Saturday evening and each participating jet returned to base without incident, the ministry further stated.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
IS - alternatively referred to as the so-called Islamic State - enforced jihadist rule over large swathes of Iraq and Syria until 2019.
"This operation shows the UK's leading role, and determination to operate in unison with allied nations, to eradicate any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the minister stated.
RAF aircraft have conducted overwatch operations over Syria to "deter any efforts to regroup" of the group after its defeat at the Baghuz confrontation in 2019, the MoD reported.
"I extend gratitude to all the members of our armed forces who took part in this strike for their skill and their valour," Healey said. "They were among a great many British personnel stationed over the festive period. This mission, to remove militants who endanger our way of life, demonstrates how British military are prepared to act, all year round, protecting the UK at home and powerful internationally."
During December, the United States armed forces executed what it called a "massive strike" against Islamic State objectives in Syria, following an ambush resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations says Daesh still maintains roughly 5-7 thousand combatants in both countries.